Zoderm E Cream is an antifungal medicine used to treat fungal infections of the skin. It works by killing the fungus that causes infections such as athlete’s foot, Dhobie Itch, thrush, ringworm, and dry, flaky skin. Zoderm E Cream should be used in the dose and duration as prescribed by your doctor. This medicine should be used regularly to get the most benefit from it. Do not use more than you need – it will not clear your condition faster and may only increase the side effects. Skin infections will usually get better after 2 to 4 weeks. Do not use the cream for longer than your doctor has told you to and let him or her know if your condition does not improve after 2 to 4 weeks of treatment. You can help the cream work better by keeping the affected areas clean, making sure they are dry and washing your hands before and after treating the infection. If you have athlete’s foot, wash your socks or tights thoroughly and change your shoes daily if possible.The most common side effects of using this cream include a burning sensation and irritation, dryness, peeling or blistering of the skin. These are not usually serious, but you should call your doctor if you think you might have a severe allergic reaction. Signs of this include rash, swelling of the lips, throat or face, swallowing or breathing problems, feeling dizzy or faint and nausea. Get emergency help if this happens. Avoid direct contact of the cream or ointment with your eyes. In case of direct contact, wash your eyes with water and seek immediate medical attention.it is not likely that other medicines you take by mouth or injection will affect the way this medicine works, but talk to your doctor before using it if you have recently used another cream that contains a steroid or had an allergic reaction to another antifungal medicine. This cream should only be used if it is clearly needed if you are pregnant or breastfeeding. Ask your doctor if it is safe.