Mesacol 500mg Suppository is a medicine used to treat Crohn’s disease and ulcerative colitis. It is used when the lining tissue of the inner rectum becomes inflamed (proctitis). It helps to reduce symptoms such as diarrhea, bleeding, and stomach pain by reducing inflammation in the bowel. Mesacol 500mg Suppository is only for the rectal route and should not be taken orally. It must be used under the supervision of a doctor or healthcare professional. Stay in a lying position for at least 15 minutes after the insertion of suppositories. The dose will depend on what you are being treated for, but take it exactly as your doctor prescribes. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early, your symptoms may come back, and your condition may worsen.The most common side effects of this medicine include rectal discomfort, rash, itching, and fever. If these symptoms bother you or do not go away or get worse, tell your doctor. There may be ways of reducing or preventing them.Before taking it, tell your doctor if you have any kidney or liver problems or a blockage in your stomach. Your age may also be a factor in deciding whether this medicine is suitable. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Let your doctor know about all other medications you are taking, as some may affect or be affected by this medicine. You may be asked for kidney and liver function tests before and after the treatment.